Idiopathic normal pressure hydrocephalus: associations between CSF biomarkers, clinical symptoms, and outcome after shunt surgery

Table 4 Correlations stronger than r_p=0.25 between preoperative symptom scores and biomarker concentrations

	NFL(ln)	T-tau(ln)	P-tau(ln)	Aβ42
Cognition (iNPH-scale)	-0.36**	-0.39**	-0.26*
Identical forms test (0–60)	-0.25*	-0.39***	-0.33**
Bingley (0–12)	-0.29**	-0.34**
SSCD (1–4)	0.46***	0.35**	0.31**
Daily need of sleep (h)	0.35**	0.30*
Stroop C Stroop I	0.34 0.51	0.37**	0.26*
Grooved pegboard	0.38**	0.31*
RAVLT	-0.33**	-0.39**	-0.30**
Gait (iNPH scale)	-0.27*			-0.25*
Ordinal gait rating (1–6)	0.28*
Balance (iNPH scale)	-0.39**
Urgency (iNPH scale)	-0.25*

Nota bene: logarithmic values for NFL, T-tau and P-tau. *=p < 0.05; **=p < 0.01; ***=p < 0.001. iNPH scale domain scores in bold. All correlations represent associations where a higher biomarker concentration is associated with a poorer test performance.

ISSN: 2045-8118