Idiopathic normal pressure hydrocephalus: associations between CSF biomarkers, clinical symptoms, and outcome after shunt surgery

Table 3 Regression analyses with the biomarkers as independent variables and the total iNPH-scale score before shunt surgery as dependent variable

Biomarker	Standardized B	95%CI for B	Adjusted r²	p-value	p-value	p-value
		(Lower– upper)		Univariable regression	Multivariable regression*	Adjustment for age
Aβ38	-0.210	-0.017–0.000	0.032	0.060	0.243	0.567
Aβ40	-0.241	-0.008–0.000	0.046	0.030	0.373	0.710
Aβ42	-0.204	-0.063–0.002	0.029	0.068	0.418	0.603
sAPPα	0.110	-0.013–0.039	0.000	0.330	-
sAPPβ	0.128	-0.016–0.061	0.004	0.255	-
MCP-1	-0.096	-0.060–0.024	-0.003	0.395	-
ln-T-tau	-0.304	-22.47– -3.586	0.080	0.007	0.047	0.110
ln-P-tau	-0.195	-24.24–1.662	0.025	0.087	0.138	0.192
ln-NFL	-0.375	-19.317– -5.563	0.130	< 0.001	0.351	0.565

*Biomarkers with p-values < 0.1 were included in the multivariable regression. Significant p-values in bold. Adjustment for age = multivariable regression with adjustment for age.

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