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Table 1 Demographic data of the 81 patients with idiopathic normal pressure hydrocephalus

From: Idiopathic normal pressure hydrocephalus: associations between CSF biomarkers, clinical symptoms, and outcome after shunt surgery

 

All

(n = 81)

AD negative (n = 50)

AD positive (n = 31)

 

Age, mean (range)

73.3 (52–89)

72.3 (7.3)

74.8 (56–86)

p = 0.10

Sex, n (%)

    

 Female

 Male

29 (36%)

52 (64%)

15 (30%)

35 (70%)

14 (45%)

17 (55%)

p = 0.23

Risk factors, n (%)

    

 Hypertension

 Cardiovascular disease

 Diabetes

43 (53%)

26 (33%)

18 (23%)

29 (58%)

18 (36%)

14 (28%)

14 (47%)

8 (27%)

4 (13%)

p = 0.36

p = 0.46

p = 0.17

MMSE, mean (SD)

Preop iNPH scale score, mean (SD)

23.6 (4.4)

47.8 (20.3)

24.2 (4.0)

49.7 (21.3)

22.7 (4.9)

45.1 (18.9)

p = 0.21

p = 0.49

Improved, n (%)

48 (59%)

40 (60%)

18 (58%)

p = 1.0

  1. MMSE = Mini Mental State Examination. AD = Alzheimer’s disease pathology defined by CSF Aβ42/Aβ40-ratio. AD negative and AD positive patients are defined by Aβ42/Aβ40-ratio above or below 0.09 respectively. Improved = postoperative iNPH scale score increase of at least 5 points. P-values are given for comparisons of AD negative vs. AD positive patients.
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Fluids and Barriers of the CNS

ISSN: 2045-8118