Fig. 5
PKA inhibition lowers CSF secretion and K+ efflux from the choroid plexus. A Representative trace of fluorescent dye dilution over the course of a ventriculo-cisternal perfusion assay in a control rat. The first grey box indicates the values employed as control rate and the second those employed to obtain the percentage change in CSF secretion rate. B Summarized CSF secretion rates shown as percentage of own control after infusion with vehicle (control; Ctrl) or the PKA inhibitor H89, n = 4–6. C Efflux rate constant for 86Rb+ from acutely excised choroid plexuses treated with vehicle (Ctrl) or H89, n = 5 of each. Results are shown as mean ± SEM. Statistical significance was evaluated with Student’s unpaired t-test. **; P < 0.01