Fig. 7
From: The glycosaminoglycan chains of perlecan regulate the perivascular fluid transport
Hspg2∆3∆91;5xFAD mice show no alterations in amyloid-β (Aβ) load in the brain parenchyma. A) Timeline of the experiment showing the timing of sample collection. B) Images of brain sections (Aβ, red) from the Hspg2+/+;5xFAD and Hspg2∆3∆91;5xFAD mice at 6 months (n = 12) and 12 months (n = 9) of age. C-E) Quantification of Aβ (red) in the whole brain section. F-H) Quantification of Aβ (red) in the hippocampus (white dashed line). Scale bar, 1 mm (B). The statistical test used was 2-way ANOVA followed by Sidak’s post-hoc test (B-G). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. ns, non-significant. Mean ± SEM