Fig. 2

TMA concentration curves for each replicate of young adult mice from Kress [25], generated from data for void volume, tortuosity, and uptake using RTI equations from Nicholson [14]. The replicates demonstrate experimental variability, where range is 88% and the standard deviation in \(C_{max}\) is 36%. The inset shows an RTI experimental set up, where source and detection probes are inserted into brain tissue. The source probe delivers molecules to the brain tissue; the detection probe measures the concentration of those molecules over time. Analysis of the resulting concentration curve provides an estimate of α and λ